Knocking two rooms together is the easy part. Making the result feel deliberate rather than merely large is what the plan is for.
Every timber marks. The question is whether it marks in a way you will come to like, and that is mostly a question of species and finish.
A desk in a spare room has to disappear at weekends. That is a storage problem long before it is a furniture problem.
An hour in your house tells us more than a week of photographs. This is what the hour is spent on.
A colour chosen under showroom lighting is a different colour in a north-facing room in November. Test it where it has to live.
The last two days of a project decide how the whole thing is remembered. They are worth planning as carefully as the first two.